Pronunciation: C1 ES-ter-ase in-HIB-i-ter
Generic Name: C1 Esterase Inhibitor (Human)
Brand Name: Berinert
Berinert is used for:
Treating stomach or facial attacks in teenagers and adults with hereditary angioedema (HAE).
Berinert is a C1 esterase inhibitor (human). It works by helping to control inflammation and parts of the immune system. This helps to prevent the swelling and/or painful attacks that occur with hereditary angioedema (HAE).
Do NOT use Berinert if:
- you are allergic to any ingredient in Berinert or have had a severe allergic reaction (eg, rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness) to Berinert or another C1 esterase inhibitor
Contact your doctor or health care provider right away if any of these apply to you.
Before using Berinert:
Some medical conditions may interact with Berinert. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
- if you are pregnant, planning to become pregnant, or are breast-feeding
- if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
- if you have allergies to medicines, foods, or other substances
- if you have a history of blood or clotting problems, such as blood clots in your veins or lungs (eg, deep vein thrombosis, pulmonary embolism)
Some MEDICINES MAY INTERACT with Berinert. However, no specific interactions with Berinert are known at this time.
Ask your health care provider if Berinert may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
How to use Berinert:
Use Berinert as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- An extra patient leaflet is available with Berinert. Talk to your pharmacist if you have questions about this information.
- Berinert is usually given as an injection at your doctor's office, hospital, or clinic. If you will be using Berinert at home, a health care provider will teach you how to use it. Be sure you understand how to use Berinert. Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions.
- Do not use Berinert if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.
- This product must be used within 8 hours after mixing.
- Keep this product, as well as syringes and needles, out of the reach of children and pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.
- If you miss a dose of Berinert, contact your doctor right away.
Ask your health care provider any questions you may have about how to use Berinert.
Important safety information:
- Berinert may contain albumin, which comes from human blood. There is a very rare risk of getting a viral disease or a central nervous system disease called Creutzfeldt-Jakob disease from products with albumin. No cases of these problems have been found in patients who have used Berinert.
- The risk of blood clots (eg, in your veins or lungs) may be increased with high doses of Berinert. Tell your doctor if you have a history of blood clotting problems. Contact your doctor right away if you develop symptoms of a blood clot (eg, changes in consciousness, speech, or vision; one-sided weakness or loss of muscle control; severe or persistent headache; chest pain; shortness of breath; pain, numbness, or swelling in your arms, legs, or stomach) while you are using Berinert. Talk with your doctor for more information.
- Tell your doctor or dentist that you take Berinert before you receive any medical or dental care, emergency care, or surgery.
- Berinert should be used with extreme caution in CHILDREN younger than 12 years old; safety and effectiveness in these children have not been confirmed.
- PREGNANCY and BREAST-FEEDING: It is not known if Berinert can cause harm to the fetus. If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Berinert while you are pregnant. It is not known if Berinert is found in breast milk. If you are or will be breast-feeding while you use Berinert, check with your doctor. Discuss any possible risks to your baby.
Possible side effects of Berinert:
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Diarrhea; headache; mild injection-site pain or redness; muscle spasms; nausea, stomach pain, or vomiting.
Seek medical attention right away if any of these SEVERE side effects occur:
Severe allergic reactions (rash; hives; itching; difficulty breathing or shortness of breath; tightness in the chest; fast heartbeat; severe dizziness or lightheadedness; fainting; swelling of the mouth, face, lips, or tongue; blue gums or lips; wheezing; unusual hoarseness); dark urine; fatigue; numbness or tingling; severe nausea or stomach pain; severe or persistent injection-site pain or redness; symptoms of infection (eg, fever, sore throat, cough); weakness; yellowing of the skin or eyes.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.
See also: Berinert side effects (in more detail)
If OVERDOSE is suspected:
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include changes in consciousness, speech, or vision; one-sided weakness or loss of muscle control; severe or persistent headache; chest pain; shortness of breath; pain, numbness, or swelling in your arms, legs, or stomach.
Proper storage of Berinert:
Berinert is usually handled and stored by a health care provider. If you are using Berinert at home, store Berinert as directed by your pharmacist or health care provider. Keep Berinert out of the reach of children and away from pets.
General information:
- If you have any questions about Berinert, please talk with your doctor, pharmacist, or other health care provider.
- Berinert is to be used only by the patient for whom it is prescribed. Do not share it with other people.
- If your symptoms do not improve or if they become worse, check with your doctor.
- Check with your pharmacist about how to dispose of unused medicine.
This information is a summary only. It does not contain all information about Berinert. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.
More Berinert resources
- Berinert Side Effects (in more detail)
- Berinert Use in Pregnancy & Breastfeeding
- Berinert Support Group
- 0 Reviews for Berinert - Add your own review/rating
- Berinert Prescribing Information (FDA)
- Berinert Consumer Overview
- Berinert Advanced Consumer (Micromedex) - Includes Dosage Information
- Cinryze Prescribing Information (FDA)
- Cinryze Consumer Overview
- Cinryze Monograph (AHFS DI)
Compare Berinert with other medications
- Hereditary Angioedema
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